Dentistry Today

New Haven, Conn. — Wrinkles are a telltale sign of aging, and they might also be able to predict a womans bone fracture risk, according to Yale School of Medicine researchers who report in a new study that the severity and distribution of skin wrinkles and overall skin quality could tell the story of bone mineral density in early menopausal women.

The findings will be presented June 6 at the Endocrine Society Meeting in Boston, Mass., by Lubna Pal, associate professor in the Department of Obstetrics, Gynecology & Reproductive Science at Yale School of Medicine.

“Skin and bones share common building blocks-proteins, and aging is accompanied by changes in skin and deterioration of bone quantity and quality,” said Pal, who, along with the research team, had hypothesized that in postmenopausal women, the quality of an individual woman’s skin-the degree of wrinkling and hardening-will reflect the status of her bones.

Pal and her research team studied this theory in a subgroup of early menopausal women within three years of their last menstrual period who are enrolled in the ongoing clinical trial, the Kronos Early Estrogen Prevention Study (KEEPS). T

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